Simparica Trio

Simparica Trio

No need to introduce the fight against fleas, ticks, and others among dog owners. Besides being irritating, these little bugs may be quite hazardous to your companion's health. That is where the Simparica Trio comes in one of the most popular solutions among veterinarians for maintaining your dog's safety and health. In this article, we go in-depth on what Simparica Trio is, how it works, its side effects, pricing, and more, whether you're a first-time pet parent or a seasoned pro. And this guide will cover all the information you may need.

What is Simparica Trio?

Simparica Trio combines the efficacy required to protect dogs from fleas, ticks, heartworms, and intestinal parasites such as roundworms and hookworms in one chewable tablet. Made by Zoetis, the leading global animal health company, the product has quickly gained speed to be the go-to for all pet owners looking for an effective and efficient means of keeping their dogs parasite-free.

It goes without saying that the Simparica Trio is very convenient. No more worrying about how to give different medicines to cover different parasites; one tablet does it all. It keeps your dog safe from a whole host of common parasites that can cause considerable health problems if given monthly.

How does the Simparica Trio work?

The active ingredients of Simparica Trio include sarolaner, moxidectin, and pyrantel. Because each one of these targets different kinds of parasites, the method for treating them has a wide range.

Sarolaner is an effective systemic ectoparasiticide that kills fleas and ticks. That works by interfering with these pests' nervous systems, resulting in their deaths.
Moxidectin: This constituent kills the larvae of the heartworm before they develop, so it can be harmful to cause heartworm disease.
Pyrantel: Pyrantel acts on intestinal worms such as roundworms and hookworms, prevents them from attaching to the walls of intestines, and thus is prevented from causing any harm to your dog.
In a nutshell, all three active ingredients offer a broad-spectrum profile in one easy-to-administer chewable tablet.

Simparica Trio Dosage

Dosage is one of the essentials in effectively giving Simparica Trio. The weight here plays an important role, wherein you need to base it on the instructions given by your veterinarian.

The general guideline looks something like this:

  • 2.8 to 5.5 lbs: 1.2 mg sarolaner, 0.24 mg moxidectin, 5 mg pyrantel
  • 5.6 to 11 lbs: 2.4 mg sarolaner, 0.48 mg moxidectin, 10 mg pyrantel
  • 11.1 to 22 lbs: 6 mg sarolaner, 1.2 mg moxidectin, 25 mg pyrantel
  • 22.1 to 44 lbs: 12 mg sarolaner, 2.4 mg moxidectin, 50 mg pyrantel
  • 44.1 to 88 lbs: 24 mg sarolaner, 4.8 mg moxidectin, 100 mg pyrantel
  • 88.1 to 132 lbs: 36 mg sarolaner, 7.2 mg moxidectin, 150 mg pyrantel


It is always important to speak with your veterinarian to make sure you are giving the correct dosage amount for your specific dog. The consequences of overdosing or underdosing will be reduced effectiveness or possible side effects.

Is Simparica Safe for Puppies?

If you have a younger dog and are considering the Simparica Trio, you might wonder: Is Simparica safe for puppies? Your answer is yes, but with some age and weight restrictions.

It is safe for Simparica Trio puppies to start at 8 weeks of age, provided they weigh at least 2.8 pounds. Of course, follow these guidelines to avoid some type of adverse reaction. Safety in puppies weighing 2.8–15.3 lbs was tested in a product. The efficacy and tolerance were well documented using the recommended dose.

But, like with any medication, it is essential to monitor your puppy for any severe reactions when administering the initial few doses of the tablet. If you notice anything that concerns you, you should immediately call your veterinarian.

Side Effects of the Simparica Trio

Adverse reactions to Simparica Trio are uncommon, but as with any medication, they can be observed in some individual dogs. That's why it's so important to be aware of the potential side effects and know what to look for so you can take the appropriate action if your dog seems uncomfortable in any way.

Common side effects include:

Vomiting: After administering Simparica Trio, a few dogs vomited. If that happens, your vet may find another type of treatment more effective for your pet.


  • Diarrhea: This is another possible side effect, mainly in those dogs that have rather sensitive stomachs.
  • Lethargy: Your dog may be very tired or lethargic after taking medication. It may be temporary, but if he remains this way, seek advice from your veterinarian.
  • Loss of Appetite: Following the administration of Simparica Trio, there may be a period when food intake is reduced by your dog.
  • Neurological Reactions: Less common, more serious side effects with dogs may include the following: tremors and seizures, or unusual walking. These are rare but need immediate veterinary attention.
It would be worth weighing the benefits against possible risks, and always consult your vet if you have any concerns. In case your dog has a seizure or other neurological disorders in the past, make sure that the history is mentioned to the veterinarian before putting them on Simparica Trio.

Simparica Trio Rebate: How to Save Money

Having to purchase a pet's medications can be very expensive at times; hence, many people owning pets are always on the lookout for ways they could save money. If you are looking to shave off some of the costs associated with Simparica Trio, then continue reading as information about the Simparica Trio rebate program is discussed.

The manufacturer of Simparica Trio, Zoetis, usually offers some rebate programs that would help pet owners save money on their purchases. These types of rebates help balance the cost of medication for more effective use over some time.

In most instances, you will be required to buy a certain number of doses from a veterinarian or a participating retailer to get the rebate. Sometimes, after making a purchase, one has to mail or go online with the receipt and, upon approval, get either a check or a prepaid card with the rebate on it.

Because rebate amounts are subject to change, it's always worth checking the Zoetis website or asking your vet for current offers before you make a purchase. Participating in a rebate program will save you quite a bit throughout your dog's treatment.

Simparica Trio Price: What to Expect

Simparica Trio Cost Probably the most frequent question about Simparica Trio is simply, How much is Simparica Trio for dogs? It's not a straightforward answer, though, because there are a few determining factors in how much it will cost: the size of your dog, where purchased, and buying in bulk or not.

You can expect to pay an average of $130-$200 for a 6-month supply of Simparica Trio. Larger dogs require higher dosages, therefore increasing the cost. You can usually save money by buying a 6- or 12-month supply rather than purchasing one dose at a time each month.

It would also be worth inquiring with your veterinarian about any special promotions or discounts available and checking online pharmacies that may also have competitive pricing. Just make sure to buy from a reputable source to ensure you get the genuine product.

How to Help Your Dog Stay Healthy with Simparica Trio

Now that you know some more about Simparica Trio and how it works, you want to consider how this medication fits into the big picture of your dog's overall health plan. Here are some helpful ways you can ensure your dog stays healthy and happy on Simparica Trio:

1. Regular Check-Ups
  • Even though Simparica Trio covers every aspect of protection, it is still very important that you have your dog checked regularly by a veterinarian. Your veterinarian will then be able to monitor their health, inspect them for parasites, and make any needed adjustments to dosage.

2. Healthy Diet and Exercise
  • A balanced diet and exercise will go a long way in keeping your dog in the best shape possible. A healthy dog has a better chance of fighting off an infection and recovering from potential side effects fast.

3. Be on the Lookout for Side Effects
  • As earlier emphasized, observe your dog for any side effects after the administration of Simparica Trio. This may mean all the difference in the health of your dog should there be an adverse reaction.

4. Stay Informed
  • Parasite control is an ongoing battle. Educate yourself on the newest products and research into the most effective methods of managing your pet. Again, your vet is an excellent resource, as they can help you based on your dog's needs.

Closing Thoughts on Simparica Trio

Simparica Trio is one of the major arms in this war, providing broad-spectrum protection in just one monthly tablet. Its convenience and high efficiency have made it one of the most popular options among owners and professionals. With any medication, however, there is a proper way to use it, and side effects can occur.

Knowing the Simparica Trio cost and how to maximize the available rebates of Simparica Trio, along with using the proper dosage of Simparica Trio, will go a long way in ensuring that your canine companion stays healthy and parasite-free.

Anyway, it is worth noting that in issues involving side effects related to Simparica Trio or questions concerning the safety of the product in puppies, your veterinarian will always be the best avenue to take. Follow their advice very carefully, so you can be sure that you are doing the right thing for your pet every time there is a change in the administration of medication.

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